Antibiotics have saved millions of lives since their widespread use began many decades ago. Infections that were once a death sentence were easily treated with the medications. Unfortunately, many antibiotics are now becoming ineffective because bacteria have become resistant to the drugs – they have mutated into “superbugs” that are becoming nearly impossible to treat.
The researchers tested CBD against a wide variety of bacteria, including bacteria that have become resistant to the most commonly used antibiotics. The development is important, as antibiotic resistance is reaching dangerously high levels, according to the World Health Organization.
What the Research Shows
Mark Blaskovich, PhD, senior research officer at the Centre for Superbug Solutions at the Institute for Molecular Bioscience at the University of Queensland in Australia presented the research at the American Society for Microbiology annual meeting. The research includes work in test tubes and animal models. Research presented at meetings should be viewed as preliminary until published in a peer-reviewed medical journal (source).
The first thing we looked at is CBD’s ability to kill bacteria,” he says. “In every case, CBD had a very similar potency to that of common antibiotics. DR. MARK BLASKOVICH
The researchers tested the CBD against some strains of Staphylococcus, which cause skin infections, and streptococcus, which causes strep throat. They compared how effective CBD was compared to common antibiotics, such as vancomycin and daptomycin.
We looked at how quickly the CBD killed the bacteria. It’s quite fast, within 3 hours, which is pretty good. Vancomycin (Vancocin) kills over 6 to 8 hours. DR. MARK BLASKOVICH
The CBD also disrupted the biofilm, the layer of ”goop” around bacteria that makes it more difficult for the antibiotic to penetrate and kill. Finally, the lab studies showed that “CBD is much less likely to cause resistance than the existing antibiotics,” Blaskovich says. The CBD ”is selective for the type of bacteria,” he says. He found it effective against gram-positive bacteria but not gram-negative. Gram-positive bacteria cause serious skin infections and pneumonia, among other conditions. Gram-negative bacteria include salmonella (found in undercooked foods) and E. coli (the cause of urinary tract infections, diarrhea, and other ailments), among other bacteria.
In another study, also presented at the meeting, the researchers tested topical CBD to treat a skin infection on mice. It cut the number of bacteria after 48 hours, Blaskovich says, although it did not clear the infection. That research is ongoing.
How It Might Work
The researchers can’t say exactly how the CBD may prove to be a superbug infection fighter.
- “We thought it might work by damaging the outer membrane of the bacteria, to make it leaky. It doesn’t seem to do that. It might be a completely new mechanism of action.”DR. MARK BLASKOVICH
He says the research results are promising but in early stages.
The study was funded by Botanix Pharmaceuticals Ltd., which is researching uses of CBD for skin conditions, and the Australian government. Blaskovich is a consultant for Botanix.
Brandon Novy, a microbiology researcher at Reed College in Portland, OR, calls the study findings ”very promising,” since the results show the bacteria were not able to form resistance to the CBD, and since the bacteria were not able to form a biofilm. Both findings are important. “The biofilm is an important part of the whole infection process,” he says. “It helps the bacteria attach [to whatever surface or host] and survive.”
At the same meeting, Novy presented a preliminary study, finding that CBD also looks promising to fight some gram-negative infections. “It is an important study that deserves to be followed up on,” says Amesh Adalja, MD, an infectious disease doctor and senior scholar at the Johns Hopkins Center for Health Security. He was not involved in the new study. But he cautions that ”it is important to keep it all in context. I think it is a good thing that people are looking at the use of CBD for infectious uses in a systematic way (source).